Skip to Contents
Atlas logo
lymph nodesOverview

Click on images for full-size photographs

lymph node h&e 4x thumbnail lymph nodes h&e 10x
thumbnail lymph nodes h&e 20x thumbnail lymph nodes h&e 40x

Lymphatic tissues in the mice include lymph nodes, thymus, spleen, and gut-associated lymphatic tissue (GALT). GALT includes Peyer’s patches in the gut and the diffuse lymphatic tissue in the gastrointestinal tract and respiratory system; mice have no tonsils. Lymph nodes are lymphatic structures that are distributed throughout the body and are located along lymphatic vessels. The lymph node consists of an outer cortex and an inner medulla covered by a connective tissue that forms septa into the node. Underneath the capsule is the subcapsular sinus, where lymph enters the node. The cortex is densely populated with lymphocytes, mainly T-cells, and contains highly organized lymphoid follicles consisting mainly of B cells. Upon immune stimulation these follicles form germinal centers, sites of lymphocyte proliferation. The cortex further contains high endothelial venules, postcapillary venules that are lined with high cuboidal endothelial cells and mediate the extravasation of lymphocytes from the blood into the node. The medulla consists of diffuse lymphatic tissue with large sinusoids.

The 4X micrograph is a cross section of a lymph node displaying the cortex surrounded by a capsule. The 10X micrograph shows the capsule, the subcapsular sinus, and the cortex. The 20X and 40X micrographs depict a high endothelial venule in increasing detail. The various cells present in the cortex of the lymph node are also visible in the 40X micrograph.

© 2004 Texas Histopages. All rights reserved.