Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

Papers of the Month: April, 2013

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

Science. 2013 Feb 1;339(6119):580-4

Yu MBardia AWittner BSStott SLSmas METing DTIsakoff SJCiciliano JCWells MNShah AMConcannon KFDonaldson MCSequist LVBrachtel E,Sgroi DBaselga JRamaswamy SToner MHaber DAMaheswaran S

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Click here to view PubMed abstract

 

Comments by Dr. Murray Gardner:

I selected this  recent paper in Science { 339: 580-584, 2013 ) entitled ” Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition” because the EMT phenotype is quite in vogue now and often is a consideration in GEM models and in the Veterinary Pathology diagnostic cases that we review each week at UCD. Using RNA-ISH analysis of primary human breast tumors and draining lymph nodes, the Harvard investigators find that rare tumor epithelial cells simultaneously express  both mesenchymal(M) and epithelial(E) markers .By capturing circulating tumor cells(CTC) on a microfluidic chip they find a highly enriched population of M staining cells, both singly and in clusters. Presence of circulating M cells correlated with disease progression and suggests that EMT contributes to blood borne metastases of human breast cancer.

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