Separate Stem-Cell Lineages for Breast Epithelial and Myoepithelial Cells

Paper of the Month: April, 2012

Distinct stem cells contribute to mammary gland development and maintenance

Nature. 2011 Oct 9;479(7372):189-93. doi: 10.1038/nature10573.

 

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Comments by Dr. Murray Gardner:

This paper reminds me of a human breast tumor that I collected 40 years ago and, as part of the NCI Virus Cancer Program, sent promptly at melting ice temperature to the Naval Biomedical Research Laboratory at the Alameda Naval Air Base. The research group there ( Adeline Hackett, Helene Smith, Louise Springer, Robert Owens Walter Nelson-Rees and John Riggs ) were able to culture two syngeneic cell lines: one aneuploid epithelial and the other diploid myoepithelial. The primary tumor looked histologically like a carcinosarcoma ( modern day “EMT” ) . The myoepithelial cell line was derived from normal tissue peripheral to the tumor. Both cell lines were free of any retrovirus. At the time (1971) this was the 1st report of companion cell lines, one malignant and one normal, established from the same organ ( JNCI 58: 1795-1886, 1977.Now, in view of current knowledge we can surmise that they were derived from separate stem cell lineages.

 

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