Comparative Pathology: CNS Mass

Glioblastoma Mouse Models

 

Using lentivirus vectors carrying H-Ras and Akt into the brains of adult mice that lacked one copy of p53, it has been shown that mice develop tumors phenotypically identical to human glioblastomas (Marumoto et al, 2009).  The tumors occurred most frequently in the hippocampus and subventricular zone.  The tumors contained cells that, when cultured in vitro, appeared to be cancer stem cells.

Note that both human and mouse tumors are highly cellular and have the typical palisade of nuclei surrounding areas of necrosis and prominent blood vessels.

 

Click here to see the whole slide image.

Click here to view the human pathology.

 

 

References:

Malignant tumors of the central nervous system associated with familial polyposis of the colon: report of two cases. Turcot J, Despres JP, St Pierre F.   Diseases of the colon and rectum.  1959 ; 2 : 465-468. PMID 13839882

Molecular Basis of Turcot’s Syndrome”   Hamilton et al, NEJM 332 839-847, 1995.

Digilio MC . Turcot syndrome. Atlas Genet Cytogenet Oncol Haematol.  August 2005 .
URL : http://AtlasGeneticsOncology.org/Kprones/TurcotID10026.html

Evidence for a recessive inheritance of Turcot’s syndrome caused by compound heterozygous mutations within the PMS2 gene. De Rosa M, Fasano C, Panariello L, Scarano MI, Belli G, Iannelli A, Ciciliano F, Izzo P Oncogene. 2000 ; 19 (13) : 1719-1723. PMID 10763829

Hereditary nonpolyposis colorectal cancer and related conditions. Lucci-Cordisco E, Zito I, Gensini F, Genuardi M American journal of medical genetics. Part A. 2003 ; 122 (4) : 325-334. PMID 14518071

Development of a novel mouse glioma model using lentiviral vectors. Marumoto T, Tashiro A, Friedmann-Morvinski D, Scadeng M, Soda Y, Gage F, Verma I.  Nature Medicine 15, 110 – 116 (2008) Published online: 4 January 2009 | doi:10.1038/nm.1863

 

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