Slide of the Week: Stomach Mass, September 19th, 2011

A 58 year old male presents with chief complaints of bloating, vague abdominal pain and dark black stools.  He is referred to a gastroenterologist who recommends upper and lower endoscopy.  Subsequently a mass of about 11×12 mm is removed from the stomach.

Review first the H&E stained image below.  The most likely diagnosis is:

1. Desmoid tumor
2. Inflammatory fibroid polyp
3. Schwannoma
4. Gastrointestinal stromal tumor

Stomach Mass

What immunohistochemical or gene expression tests would you order to confirm the diagnosis?

1. CD 117 (c-kit)
2. PDGFRA
3. DOG-1
4. All of the above
5. None of the above

Click here for the comparative pathology.

Click here for answers.

Reference:

Laurini JA and Carter JE, Gastrointestinal stromal tumors:  A review of the literature, Archives of Pathology and Laboratory Medicine 134:pp134-141, 2010.

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