Slide of the Week Answers: Stomach Mass, September 19th, 2011

The following are the answers to Slide of the Week: Stomach Mass, September 19th, 2011:

Answer 1: d, Gastrointestinal stromal tumor.

Answer 2: 4, All of the above.

Stomach Mass

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Stomach Mass

    Click here to see the whole slide image.

 

 

Comment:

Gastrointestinal stromal tumors (GIST) are of mesenchymal origin but are not common (2% of all GI tumors).  The definition for these tumors proposed in 2001 includes: “generally CD117+ and KIT or PDGFRA (platelet-derived growth factor receptor) mutation-driven GI tumors with histologic features of spindle cells, epithelioid and rarely pleomorphic morphology” (NIH GIST workshop, April, 2001).   About 90 to 95% of GIST tumors are CD 117 (c-kit) positive but in negative cases both identification of mutations in PDGFRA or DOG-1 (discovered on GIST-1) can be used to make the diagnosis. Note that this association between a biomarker (cKit) and a specific cancer (GIST) is a statistical correlation using inferential logic. The association is not rigorous causal relationship. For experimental proof using the modern molecular version of Koch’s Postulates, comparative genomic pathobiology is now used.

 

Click here for the comparative pathology.

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