The Center for Genomic Pathology and UC Davis Extension proudly present the availability of nine e-learning modules on Pathobiology of the Mouse. Drawn from the highly acclaimed long courses, Pathobiology of the Mouse Tier I, Parts A and B, these modules provide targeted information on specific topics of inertest to the researcher working with GEM, or those who wish to advance their knowledge in the field. The length of the modules ranges from 3 to 8 hours to complete. The series includes:
Topic 1: THE GENETICALLY ENGINEERED MOUSE AS A RESEARCH MODEL
This module is designed to explain genetic engineering in the mouse. The student will learn how the genetically engineered mouse is constructed and be introduced to the specific terminology used in the field. This section is followed by two detailed presentations describing the classic and unusual pathology that frequently occurs following genetic engineering. The pathology is illustrated both with still images and whole slide images (WSI). The latter allows the student to scan an entire stained tissue section (slide) and increase or decrease the magnification. This module is recommended for both researchers and/or pathologists to enhance their understanding of the unique features of genetically engineered mice. This comprehensive presentation will take approximately 8 hours to complete.
- How to Make A GEM
- GEM Tumor Pathology
- Classic GEM Tumors
- Mouse Nomenclature and Genetic Terminology
Topic 2: PROPER CARE OF THE RESEARCH MOUSE
This presentation is specifically designed for the investigator who is responsible for mouse colony welfare. It is valuable for researchers who are beginning to use the mouse as a research model or those wishing to improve the health and stability of their mouse colony. The first two topics present a detailed history of the mouse and the many regulations governing the use of mice. The next two topics present information on maintaining colony health and murine infectious diseases. This presentation will take approximately 3 hours to complete.
- History of the Mouse
- Regulations Governing Mouse Use in the Laboratory
- Maintaining a Healthy Mouse Colony
- Infectious Murine Diseases
Topic 3: THE FEMALE MOUSE AS A MODEL FOR REPRODUCTIVE RESEARCH
This presentation will require a minimum of five hours study to complete. The mouse has frequently been used as a model for research on female reproduction and teratology. This module has four topics which include the microanatomy of the female mouse, reproductive cycle, plus normal and abnormal embryology. Modalities include audio, video, and written text as well as the use of stained tissue sections with fixed images and whole slide images. Topics include:
- Microanatomy of the Genitourinary System
- Reproductive Cycle: Estrus
- Normal Embryo and Placenta
- Abnormal Embryo and Placenta
Topic 4: BASICS OF MURINE MICROANATOMY
This presentation will require a minimum of eight hours study to complete and is designed to review mouse microanatomy. The presentation is very extensive and is divided into organ systems. The information is presented using both still and whole slide images. The latter allow the student to scan the entire slide and change the magnification as desired. Accompanying the images are written texts and audio. This presentation would be extremely valuable for beginning researchers to review mouse histology prior to using a murine research model.
Topic 5: PATHOLOGIC PROCESSES AND BASIC HISTOTECHNIQUES
This presentation will require a minimum of seven hours study to complete. This module presents an extensive review of pathologic processes as well as the basics of tissue processing and staining. It is designed for the student who wishes a refresher in histotechniques and general pathology.
- Basic Histotechniques
- Pathologic Processes
Topic 6: THE UNIQUE FEATURES OF THE LABORATORY MOUSE
The laboratory mouse has many unique characteristics, including its immunobiology, as well as skin and hair physiology/morphology. This module presents an investigation into these attributes. The information is presented using video, audio and text. The visual technology includes still images and whole slide images. This presentation will require a minimum of three hours study to complete.
- Unique Characteristics of Laboratory Mice
- Immunobiology of Laboratory Mice
- Mouse Skin and Hair
Topic 7: BASIC INFORMATION FOR THE YOUNG INVESTIGATOR
This module presents information for any investigator who is contemplating use of a mouse model. It includes: 1. How to design an experiment, 2. How use and understand both light and electron microscopy, 3. Basic understanding of correct utilization of the clinical laboratory, and 4. Basic mouse surgical techniques using the mammary gland as a prototype. All presentations include audio, video and written text. This presentation requires a minimum of four hours study to complete.
- Experimental Design
- Light and Electron Microscopy
- Basic Clinical Pathology
- Basic Surgical Techniques
Topic 8: PATHOBIOLOGY OF THE LABORATORY MOUSE
This module presents extensive information on spontaneous tumor occurrence and pathology that appears in specific strains of laboratory mice. Also included is an extensive study on immunodeficient mice and their use in experimentation. All three topics are presented using audio, video, as well as still and whole slide images. The module is designed for all who desire an update on immunology and the occurrence of spontaneous pathology in their research animals. This presentation requires a minimum of four hours study to complete.
- Background Pathology
- Spontaneous Tumors
- Immunodeficient Mice
Topic 9: TECHNIQUES FOR STUDYING MURINE ANATOMY
Describing gross tissues is a skill best taught using algorithms. This module presents the appropriate vocabulary as well as logical algorithms for describing both gross and microscopic sections. The material is invaluable for those interested in tissue and lesion descriptions. This presentation requires a minimum of six hours study to complete.
- Gross Anatomy
- Gross Descriptive Terminology
For more information on these courses and other available courses, please visit UC Davis Extension Website: http://www.extension.ucdavis.edu/genomics
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