Slide from a 38 yo primiparous woman with a two year old child and a nipple discharge. A breast biopsy was performed.
Breast Biopsy with Ductal Hypercellularity
Your diagnosis is:
- Mastitis
- DCIS
- Atypical Hyperplasia
- Fibrocystic disease
Click here to see the whole slide image.
Click here for the comparative pathology.
Scroll below for answer.
Answer: 2, DCIS.
Comment:
Ductal Carcinoma in Situ (DCIS) of the human breast is considered by most authorities as an indicator of pending disaster. Women with this lesion are at increased risk of developing invasive cancer. Although the risk varies from study to study, all agree that these lesions appear in women with a high risk of breast cancer. Like many types of in-situ epithelial cancers, the risk seems to be related to the grade.
Reference:
Polyak K, Shipitsin M, Campbell-Marrotta L, Bloushtain-Qimron N, Park SY. Breast tumor heterogeneity: causes and consequences. Breast Cancer Res. 2009 Jun 23;11 Suppl 1:S18. [Epub ahead of print] PubMed PMID:20602816
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