Modelling schizophrenia using human induced pluripotent stem cells.

Nature. 2011 May 12;473(7346):221-5. Epub 2011 Apr 13.

 

Modelling schizophrenia using human induced pluripotent stem cells.

Kristen J. BrennandAnthony SimoneJessica JouChelsea Gelboin-BurkhartNgoc Tran,Sarah SangarYan Li,Yangling MuGong ChenDiana YuShane McCarthyJonathan SebatFred H. Gage

 

Click here for Pubmed Abstract

 

This May 2011 Nature paper from Fred Gage’s Lab at Salk Inst. is a nice example of creating a complex disease phenotype in reprogrammed fibroblasts. Fibroblasts from adults with schizophrenia were induced to become pluripotent stem cells which were subsequently differentiated into neurons. These neurons exhibited electrophysical, molecular and gene expression changes associated with  schizophrenia and these abnormalities were ameliorated by treatment of the neurons with the antipsychotic drug, loxopine. This is a remarkable result in so far as it the first time that a complex genetic psychologic disorder has been so successfully modeled in a dish.

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