Neuroendocrine tumors of the lung have been produced in the mouse using several techniques that inactivate both p53 and Rb. In the case illustrated here the mouse contained homozygous conditional knockout alleles for both p53 and Rb. Both genes become full null alleles upon Cre mediated recombination. The mouse had been intratracheally infected with AdCre and sacrificed at 18 weeks post infection. The lung did not contain macrophages. The lung contains microscopic lesions showing early neuroendocrine-like hyperplastic lesions beneath the bronchi that resemble carcinoid organization in humans.
Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, Kaufman MH, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, Rehm S, Rozengurt N, Schuller HM, Shmidt EN, Travis WD, Ward JM, Jacks T. Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res. 2004. Apr 1;64(7):2307-16. Review. Erratum in: Cancer Res. 2004 May 15;64(10):3725. PubMed PMID: 15059877.
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