Comparative Pathology: Breast Biopsy with Ductal Hypercellularity, July 11th, 2011

This illustrates a mouse mammary gland with focal ductal atypias associated with an adjacent carcinoma.

Breast Biopsy with Ductal Hypercellularity

 

The mouse has been the model for experimental breast cancer research since the 1890s. The original description of high risk lesions of the breast was in 1907.  Currently, almost every genetically engineered mouse model of breast cancer develops early in-situ lesions. These lesions can be identified in-situ in the mouse, isolated, and transplanted to study their biology. These studies have supplied support for the cancer initiating cell hypothesis with a predetermined, or imprinted, molecular profile that dictates clinical outcome.

Click here to see the whole slide image.

Click here to view the human pathology.

 

References:

Cardiff RD, Kenney N. Mouse mammary tumor biology: a short history. Adv Cancer Res. 2007;98:53-116. PubMed PMID:17433908

Damonte P, Hodgson JG, Chen JQ, Young LJ, Cardiff RD, Borowsky AD. Mammary carcinoma behavior is programmed in the precancer stem cell. Breast Cancer Res. 2008;10(3):R50. Epub 2008 Jun 3. PubMed PMID:18522749

Cardiff RD, Borowsky AD. Precancer: sequentially acquired or predetermined? Toxicol Pathol. 2010;38(1):171-9. Epub 2009 Dec 17. PubMed PMID:20019354

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