This illustrates a mouse mammary gland with focal ductal atypias associated with an adjacent carcinoma.
The mouse has been the model for experimental breast cancer research since the 1890s. The original description of high risk lesions of the breast was in 1907. Currently, almost every genetically engineered mouse model of breast cancer develops early in-situ lesions. These lesions can be identified in-situ in the mouse, isolated, and transplanted to study their biology. These studies have supplied support for the cancer initiating cell hypothesis with a predetermined, or imprinted, molecular profile that dictates clinical outcome.
Damonte P, Hodgson JG, Chen JQ, Young LJ, Cardiff RD, Borowsky AD. Mammary carcinoma behavior is programmed in the precancer stem cell. Breast Cancer Res. 2008;10(3):R50. Epub 2008 Jun 3. PubMed PMID:18522749
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