61 YO male with 3 month history of cough. Mass found in lung and excised.
Your diagnosis is:
- Squamous cell carcinoma
- Small cell carcinoma
Scroll below for answer.
Answer: 3, small cell carcinoma.
Comment: This was originally diagnosed as a small cell carcinoma of the lung. However, The cells exceed the size criteria of scanty cytoplasm and a diameter no more than three resting lymphocytic nuclei. The cytoplasm is also abundant. A panel of experts classified this as a small cell carcinoma of the lung, intermediate grade. The case illustrates the ambiguity in some of our diagnostic criteria.
den Bakker MA, Willemsen S, Grünberg K, Noorduijn LA, van Oosterhout MF, van Suylen RJ, Timens W, Vrugt B, Wiersma-van Tilburg A, Thunnissen FB. Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability. Histopathology. 2010 Feb;56(3):356-63. PubMed PMID: 20459535.
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