June 21, 2011Posted in: Slide of the Week
61 YO male with 3 month history of cough. Mass found in lung and excised.
Your diagnosis is:
- Squamous cell carcinoma
- Small cell carcinoma
Click here to see the whole slide image.
Click here for the comparative pathology.
Scroll below for answer.
Answer: 3, small cell carcinoma.
Comment: This was originally diagnosed as a small cell carcinoma of the lung. However, The cells exceed the size criteria of scanty cytoplasm and a diameter no more than three resting lymphocytic nuclei. The cytoplasm is also abundant. A panel of experts classified this as a small cell carcinoma of the lung, intermediate grade. The case illustrates the ambiguity in some of our diagnostic criteria.
Travis WD. Lung tumours with neuroendocrine differentiation. Eur J Cancer. 2009 Sep;45 Suppl 1:251-66. Review. PubMed PMID: 19775623.
den Bakker MA, Willemsen S, Grünberg K, Noorduijn LA, van Oosterhout MF, van Suylen RJ, Timens W, Vrugt B, Wiersma-van Tilburg A, Thunnissen FB. Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability. Histopathology. 2010 Feb;56(3):356-63. PubMed PMID: 20459535.
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