Numerous mouse models of NSCLC have been developed. The majority of the models use a Ras oncogene that produces a papillary adenocarcinoma. However, several models develop squamous cell carcinomas. This example uses a chemical carcinogen.
This carcinoma was produced using N-nitroso-tris-chloroethylurea, induced cutaneously (skin painting). There is hyperplasia of bronchiolar cells lining the airways and the alveolar walls are populated with atypical large nuclei indicative of squamous cell and acinar carcinomas. Coherent pale tumor areas with atypical large nuclei are squamous cells with limited keratinization.
Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, Kaufman MH, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, Rehm S, Rozengurt N, Schuller HM, Shmidt EN, Travis WD, Ward JM, Jacks T. Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res. 2004. Apr 1;64(7):2307-16. Review. Erratum in: Cancer Res. 2004 May 15;64(10):3725. PubMed PMID: 15059877.
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