This case of small cell pulmonary carcinoma of the mouse lung was created using homozygous conditional knockout alleles for both p53 and Rb. Both genes become full null alleles upon Cre mediated recombination. Mouse was intratracheally infected with AdCre and sacrificed at 28 weeks post infection.
This carcinoma was produced using N-nitroso-tris-chloroethylurea, induced cutaneously (skin painting). There is hyperplasia of bronchiolar cells lining the airways and the alveolar walls are populated with atypical large nuclei indicative of squamous cell and acinar carcinomas. Coherent pale tumor areas with atypical large nuclei are squamous cells with limited keratinization.
Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, Kaufman MH, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, Rehm S, Rozengurt N, Schuller HM, Shmidt EN, Travis WD, Ward JM, Jacks T. Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res. 2004. Apr 1;64(7):2307-16. Review. Erratum in: Cancer Res. 2004 May 15;64(10):3725. PubMed PMID: 15059877.
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