Comparative Pathology: Lung cancer, July 4th, 2011

Small cell pulmonary carcinoma

This case of small cell  pulmonary carcinoma of the mouse lung was created using homozygous conditional knockout alleles for both p53 and Rb. Both genes become full null alleles upon Cre mediated recombination. Mouse was intratracheally infected with AdCre and sacrificed at 28 weeks post infection.

Click here to see the whole slide image.

This carcinoma was produced using N-nitroso-tris-chloroethylurea, induced cutaneously (skin painting). There is hyperplasia of bronchiolar cells lining the airways and the alveolar walls are populated with atypical large nuclei indicative of squamous cell and acinar carcinomas. Coherent pale tumor areas with atypical large nuclei are squamous cells with limited keratinization.

Click here to view the human pathology.

Reference:

Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, Fraire AE, Gabrielson EW, Gunning WT, Haines DC, Kaufman MH, Linnoila RI, Maronpot RR, Rabson AS, Reddick RL, Rehm S, Rozengurt N, Schuller HM, Shmidt EN, Travis WD, Ward JM, Jacks T. Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res. 2004. Apr 1;64(7):2307-16. Review. Erratum in: Cancer Res. 2004 May 15;64(10):3725. PubMed PMID: 15059877.

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3. Comparative Pathology: Lobular Breast Cancer, March 9, 2011
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