Slide of the Week: Prostate Tumor, May 28th, 2011

Core biopsy of prostate from an elderly male.

Prostate tumor

Prostate tumor

 

Your diagnosis is:

  1. Adenocarcinoma, prostate
  2. Neuroendocrine tumor, prostate
  3. Poorly differentiated adenocarcinoma, prostate
  4. Metastatic tumor, prostate

 

Click here to see the whole slide image.

Click here for the comparative pathology.

Scroll below for answer.


 

 

 

 

 

 

 

Answer: 2

Comment: The microscopic pattern is not typical of standard adenocarcinoma of the prostate. The Cytoplasm is darker than expected and the nuclei are more pleomorphic. The exact nature of the tumor is revealed with immunohistochemistry.

Neuroendocrine tumor stained with synaptophysin

Neuroendocrine tumor stained with synaptophysin

The stain for synaptophysin verifies that this is a neuroendocrine tumor of the prostate.

Click here to see the whole slide image.


 

 

 

 

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