Slide of the Week: Lobular Breast Carcinoma, March 9, 2011

Correct histological classification of the tumor is only the first step in the modern diagnosis and treatment of the patient. Genomic pathology requires that one correlates the molecular profile with the structural phenotype.

Lobular breast cancer

This is a case of human lobular breast cancer that is characterized by infiltration of dense connective tissue by cords of cells typically seen in  single file. The molecular profile should include (Select best answer):

  1. P53 mutations
  2. Over-expression of p53
  3. Loss of CDH1 expression
  4. Overexpression of CDH1

Scroll below for answer.


 

 

 

 

 

 

 

Answer: 3. Loss of E-Cadherin (CDH1) expression either by loss of heterozygous at the genomic level or silencing the gene at the expression level is characteristic of lobular carcinoma of the breast.

Click here to view the WSI.

Click here for the comparative pathology.

References:
O’Malley FP. Lobular neoplasia: morphology, biological potential and management in core biopsies. Mod Pathol. 2010 May;23 Suppl 2:S14-25. Review. PubMed PMID: 20436498.

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