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Categories
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Featured Posts
CNS Mass, December 12th, 2011
Using lentivirus vectors carrying H-Ras and Akt into the brains of adult mice that lacked one copy of p53, it has been shown that mice develop tumors phenotypically identical…
Mouse Models of Uterine Leiomyomas, November 28th, 2011
Mouse models for study of human uterine leiomomas are not numerous. In fact, some researchers wonder if any good mouse model for this benign tumor is available. This is unfortunate…
Pancreatic Mass, November 14th, 2011
Although most human pancreatic carcinomas are thought to arise in the small pancreatic ducts, early attempts to develop pancreatic carcinomas in GEM produced acinar tumors. These early studies utilized the…
Young Female with Breast Mass, October 31st, 2011
Fat necrosis is fairly common in the mouse. This image contains fat necrosis in the bottom half, and normal lactating mammary gland in the upper right. Use the WSI to…
Li-Fraumeni Syndrome, October 17th, 2011
P53 knock out mice of various types have been developed by mouse modelers. As might be expected the germline transmission results in tumors in multiple organs. The genesis of tumors…
Hereditary Multiple Exostosis, October 3rd, 2011
Chondrosarcomas occur in mice with conditional inactivation of the gene, exostoses (multiple) 1 (Ext1) and in some varieties of CD1 and NOD mice. This image shows a tibial lesion with…
Stomach Mass, September 19th, 2011
Direct experimental proof that a mutatant cKit causes GIST is provided by inserting the mutant gene into the mouse genome. Amazingly, the same gene identified in the human GIST causes…
Medullary Thyroid Cancer, September 5th, 2011
Medullary carcinoma of the thyroid gland of 485 days old Rb+/- female mouse. Courtesy of Dr. Alexander Nikitin, Cornell University. Remember that Rb LOH contributes to neuroendocrine tumorigenesis in…
Elevated WBC Following Stress Event, August 8th, 2011
In the mouse, the total WBC count is significantly influenced by the site of blood collection and the time of day – variations up to 30 times can be within…
Mammary Gland Biopsy, August 22th, 2011
The laboratory mouse has long been the model for atypical hyperplasia. This is an image from the 1911 report by Haaland. He recognized, as did Apolant, that these hyperplastic nodules…
Featured Stories
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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Papers of the Month: April, 2013 Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition Science. 2013 Feb 1;339(6119):580-4 Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells…
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Novel Genital Alphapapillomaviruses in Baboons (Papio hamadryas Anubis) With Cervical Dysplasia
Papers of the Month: February, 2013 Novel Genital Alphapapillomaviruses in Baboons (Papio hamadryas Anubis) With Cervical Dysplasia Vet. Pathol. 2013 Jan;50(1):200-8. Bergin IL, Bell JD, Chen Z, Zochowski MK, Chai…
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Novel Polyomavirus associated with Brain Tumors in Free-Ranging Raccoons, Western United States
Papers of the Month: January, 2013 Novel Polyomavirus associated with Brain Tumors in Free-Ranging Raccoons, Western United States Emerg Infect Dis. 2013 Jan;19(1):77-84. Dela Cruz FN Jr, Giannitti F, Li…
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Larry Young Memorial
Larry Young passed away recently. Included is a download link that includes memorable events of Larry’s life. Larry Young Files Tweet
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Groundbreaking New Course in Mouse Pathobiology
UC Davis Extension and Center for Genomic Pathology launch second tier of this unique program. Davis, CA (PRWEB). Released on May 03, 2012 The Center for Genomic Pathology and UC…
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Experiment of the Month
Follow the development of Jane Chen and Jesse Engelberg’s studies of TEB (Terminal End Buds) here. Check back for more information in the future. Tweet
Slide of the Week
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Slide of the Week: CNS Mass, December 12th, 2011
Posted on December 12, 2011 | No CommentsA 20 year old HIV positive male presents with headache, nausea and vomiting following a seizure. History is notable for three surgeries to remove colonic polyps. Subsequent MRI brain scan...
Editor's Picks
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ONLINE TRAINING
Click here to view information session This is a special information session about a unique new online program developed by UC Davis Extension in collaboration with the Center for Genomic…

Murray's Choice of the Month
by Dr. Murray Gardner
by Dr. Murray Gardner
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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Posted on April 1, 2013 | No CommentsPapers of the Month: April, 2013 Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition Science. 2013 Feb 1;339(6119):580-4 Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells...






