Using lentivirus vectors carrying H-Ras and Akt into the brains of adult mice that lacked one copy of p53, it has been shown that mice develop tumors phenotypically identical…

Mouse models for study of human uterine leiomomas are not numerous.  In fact, some researchers wonder if any good mouse model for this benign tumor is available.  This is unfortunate…

Although most human pancreatic carcinomas are thought to arise in the small pancreatic ducts, early attempts to develop pancreatic carcinomas in GEM produced acinar tumors. These early studies utilized the…

Fat necrosis is fairly common in the mouse.   This image contains fat necrosis in the bottom half, and normal lactating mammary gland in the upper right.  Use the WSI to…

P53 knock out mice of various types have been developed by mouse modelers. As might be expected the germline transmission results in tumors in multiple organs. The genesis of tumors…

Chondrosarcomas occur in mice with conditional inactivation of the gene, exostoses (multiple) 1 (Ext1) and in some varieties of CD1 and NOD mice. This image shows a tibial lesion with…

Direct experimental proof that a mutatant cKit causes GIST is provided by inserting the mutant gene into the mouse genome. Amazingly, the same gene identified in the human GIST causes…

  Medullary carcinoma of the thyroid gland of 485 days old Rb+/- female mouse.  Courtesy of Dr. Alexander Nikitin, Cornell University. Remember that Rb LOH contributes to neuroendocrine tumorigenesis in…

In the mouse, the total WBC count is significantly influenced by the site of blood collection and the time of day – variations up to 30 times can be within…

The laboratory mouse has long been the model for atypical hyperplasia. This is an image from the 1911 report by Haaland.  He recognized, as did Apolant, that these hyperplastic nodules…